Find answers to frequently asked questions about our CASA system
CASA (Computer Assisted Semen Analysis) provides objective, reproducible measurements of sperm concentration and motility that are impossible to achieve with manual methods. Manual semen analysis is highly subjective and prone to significant inter-operator variability. CASA eliminates this subjectivity while providing additional kinematic parameters that give deeper insights into sperm function.
SAMi has been validated against the haemocytometer gold standard with peer-reviewed publication support. Our validation data spans 8 years across multiple centers, demonstrating an overall difference of just 1% between SAMi and haemocytometer measurements. We provide a comprehensive validation protocol for laboratories wishing to verify performance.
SAMi measures sperm concentration, motility grades (progressive, non-progressive, immotile), and advanced kinematic parameters including VCL (curvilinear velocity), VSL (straight-line velocity), VAP (average path velocity), LIN (linearity), ALH (amplitude of lateral head displacement), and BCF (beat cross frequency). These parameters provide comprehensive insights into sperm function.
The basic SAMi package includes a microscope with phase contrast (usually x10 objective), a dedicated video camera capturing at 60 frames per second, and a PC. We offer flexible configurations including mini hub PCs, touchscreen all-in-one systems, or integration with your existing setup. Optional accessories include Cell Vision slides and heated microscope stages.
SAMi saves an average of 14-15 minutes per sample compared to WHO-recommended manual methods for sperm concentration and motility. Recording takes approximately 10 seconds with full analysis complete in 2-3 minutes. This allows laboratories to process more samples while maintaining high accuracy.
Yes, SAMi is fully aligned with WHO 2021 (6th Edition) guidelines and ISO 23162:2021 standards. The system supports the WHO four-category motility classification and meets international quality requirements for semen analysis.
Sperminator was the name of the prototype originally developed before coming to market in 2013. The name stuck until the system was re-launched as SAMi in the spring of 2017. The validation data from Sperminator remains applicable as the core technology is the same.
Yes, SAMi includes a built-in database but also allows data export in CSV format for easy integration with other laboratory information management systems. Additionally, raw track data (X,Y coordinates for each sperm over 60 frames) can be exported for advanced research analysis.
Yes, comprehensive training is provided with every SAMi system. We also offer ongoing support, tutorials, and access to our EQA (External Quality Assessment) scheme to help maintain and verify your laboratory's performance over time.
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